|Mutations associated with resistance||Mutations associated with « possible resistance »|
|LPV/r|| At least 4 mutations among: L10F/I/R/V, K20M/R, L24I, L33F, M46I/L, I50V, F53L, I54M/L/T/V, L63P, A71I/L/V/T, V82A/F/S/T, I84V, L90M [1, 2, 3, 13]|
I47A [8, 9]
L76V [11, 12]
|3 mutations among: L10F/I/R/V, K20M/R, L24I, L33F, M46I/L, I50V, F53L, I54M/L/T/V, L63P, A71I/L/V/T, V82A/F/S/T, I84V, L90M [1, 2, 3, 13]|
300/100 mg QD
| I50L |
At least 3 mutations among: L10F/I/V, G16E, L33F/I/V, M46I/L, D60E, A71V/T, I84V, I85V, L90M [5, 7, 14, 23]
|2 mutations among: L10F/I/V, G16E, L33F/I/V, M46I/L, D60E, A71V/T, I84V, I85V, L90M [5, 7, 14, 23]|
500/200 mg BID
|At least a score of + 3* : M36I/L/V – F53L/W/Y + Q58E + H69I/K/N/Q/R/Y + L89I/M/R/T/V [6, 15]||A score of + 2*: M36I/L/V – F53L/W/Y + Q58E + H69I/K/N/Q/R/Y + L89I/M/R/T/V [6, 15]|
600/100 mg BID800/100 mg QD
| At least 4 mutations among: V11I, V32I, L33F, I47V, I50V, I54L/M, T74P, L76V, I84V, L89V [10, 16, 17, 18, 19]|
At least 2 mutations among: V11I, V32I, L33F, I47V, I50V, I54L/M, T74P, L76V, I84V, L89V [10, 16, 17, 18, 19]
|3 mutations among: V11I, V32I, L33F, I47V, I50V, I54L/M, T74P, L76V, I84V, L89V [10, 16, 17, 18, 19]|
LPV: lopinavir, ATV:atazanavir, TPV: tipranavir, DRV : darunavir, RTV: ritonavir.
For indinavir, saquinavir, nelfinavir and fosamprenavir refer to previous rules (See Archives, September 2017, version 27).
* Insufficient data for HIV-1 subtype non-B.
** Please note that rules are different for DRV/RTV 600/100 mg BID and 800/100 mg QD.
For DNA provirus, Impact of stop codons and G to A mutations on ARV resistance is unknown.
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