|Mutations associated with resistance||Mutations associated with « possible resistance »|
|LEN|| L56I |
Q67H/K/N [1,3,4, 5]
T107A/C/N [1,3, 4]
LEN : lenacapavir
1/ Yant SR, Mulato A, Hansen D et al. In vitro resistance profile of GS-6207, a first-in-class picomolar HIV capsid inhibitor in clinical development as a novel long-acting antiretroviral agent. Tenth IAS Conference on HIV Science, Mexico City, Mexico, 2019. Poster TUPEA075.
2/ Molina JM Segal-Maurer S, Stellbrink HJ et al. Efficacy and safety of long-acting subcutaneous lenacapavir in phase 2/3 in heavily treatment-experienced people with HIV: week 26 results (Capella study). IAS 2021, Abstract OALX01LB02.
3/ Ogbuagu O, Segal-Maurer S, Brinson C et al. Long-Acting Lenacapavir in People With Multidrug-Resistant HIV-1: Week 52 Results (Capella Study). CROI 2022, Abstract 491.
4/ Margot N et al. Resistance analysis of long-acting Lenacapavir in highly treatment-experienced people with HIV after 52 weeks of treatment. Poster EPB240. 24th International AIDS Conference July 2022.
5/ Vanderveen L et al. Resistance analysis of long-acting lenacapavir in treatment-naïve people with HIV at 54 weeks. Poster EPB239, 24th International AIDS Conference July 2022.