Nucleoside and nucleotide reverse transcriptase inhibitors
|Mutations associated with resistance||Mutations associated with « possible resistance »|
|ZDV|| T215A/C/D/E/G/H/I/L/N/S/V/Y/F [1, 2, 3, 4]|
At least 3 mutations among: M41L, D67N, K70R, L210W, K219Q/E [1, 2, 3, 4]
Insertion at codon 69
|3TC/FTC|| K65R [8, 9, 11]|
Insertion at codon 69
|ABC|| At least 3 mutations among: M41L, D67N, M184V/I, L210W, T215A/C/D/E/G/H/I/L/N/S/V/Y/F [5, 20]|
K65R [6, 8, 9, 24]
L74V/I [16, 17, 18, 19, 20, 24]
Insertion at codon 69
| 2 mutations among: M41L, D67N, L210W, T215A/C/D/E/G/H/I/L/N/S/V/Y/F [5, 20]|
|TDF/TAF|| At least 4 mutations among: M41L, E44D, D67N, T69D/N/S, L74V/I, L210W, T215A/C/D/E/G/H/I/L/N/S/V/Y/F [10, 12, 21, 25, 26]|
K65R/E/N [6, 7, 8, 9, 22, 23, 25, 26]
Insertion at codon 69
K70E [13, 14, 15]
|3 mutations among: M41L, E44D, D67N, T69D/N/S, L74V/I, L210W, T215A/C/D/E/G/H/I/L/N/S/V/Y/F [10, 12, 21, 25, 26]|
|ISL||M184V/I [27,28,29]||A114S |
ZDV: zidovudine, 3TC: lamivudine, FTC: emtricitabine, ddI: didanosine, d4T: stavudine, ABC: abacavir, TDF: tenofovir, TAF : tenofovir alafenamide, ISL: islatravir.
For didanosine and stavudine refer to previous rules (See Archives, September 2017, version 27)
For DNA provirus, impact of stop codons and G->A mutations on ARV resistance is unknown.
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21/ Wirden M, et al. Antiretroviral combinations implicated in emergence of the L74I and L74V resistance mutations in HIV-1-infected patients. AIDS. 2009 Jan 2;23(1):95-9.
22/ Fourati S et al. Identification of a rare mutation at reverse transcriptase Lys65 (K65E) in HIV-1-infected patients failing on nucleos(t)ide reverse transcriptase inhibitors. J Antimicrob Chemother. 2013 Jun 19.
23/ Ross LL et al. A rare HIV reverse transcriptase mutation, K65N, confers reduced susceptibility to tenofovir, lamivudine and didanosine. AIDS 2006 Mar 21;20(5):787-9.
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