Nucleoside and nucleotide reverse transcriptase inhibitors
| Mutations associated with resistance | Mutations associated with « possible resistance » | |
| ZDV |  T215A/C/D/E/G/H/I/L/N/S/V/Y/F [1, 2, 3, 4] At least 3 mutations among: M41L, D67N, K70R, L210W, K219Q/E [1, 2, 3, 4] Q151M Insertion at codon 69 | |
| 3TC/FTC | K65R [8, 9, 11] M184V/I Insertion at codon 69 | Q151M |
| ABC | At least 3 mutations among: M41L, D67N, M184V/I, L210W, T215A/C/D/E/G/H/I/L/N/S/V/Y/F [5, 20] K65R [6, 8, 9, 24] L74V/I [16, 17, 18, 19, 20, 24] Y115F [24] Q151M Insertion at codon 69 | 2 mutations among: M41L, D67N, L210W, T215A/C/D/E/G/H/I/L/N/S/V/Y/F [5, 20] M184V/I [24] |
| TDF/TAF | At least 4 mutations among: M41L, E44D, D67N, T69D/N/S, L74V/I, L210W, T215A/C/D/E/G/H/I/L/N/S/V/Y/F [10, 12, 21, 25, 26] K65R/E/N [6, 7, 8, 9, 22, 23, 25, 26] Insertion at codon 69 K70E [13, 14, 15] | 3 mutations among: M41L, E44D, D67N, T69D/N/S, L74V/I, L210W, T215A/C/D/E/G/H/I/L/N/S/V/Y/F [10, 12, 21, 25, 26] |
| ISL | M184V/I [27,28,29] | A114S [29] |
ZDV: zidovudine, 3TC: lamivudine, FTC: emtricitabine, ddI: didanosine, d4T: stavudine, ABC: abacavir, TDF: tenofovir, TAF : tenofovir alafenamide, ISL: islatravir.
For didanosine and stavudine refer to previous rules (See Archives, September 2017, version 27)
For DNA provirus, impact of stop codons and G->A mutations on ARV resistance is unknown.
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