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FUSION INHIBITOR

 Mutations associated with resistance

ENF

T20

  G36A/D/E/S/V [1, 2, 3, 4, 5, 6, 7]
  V38A/E/K/M
  Q40H/K/P/T
  N42D/T
  N43D/H/K/S
  L44M
  L45Q/M

ENF (T20): enfuvirtide

1/ Sista P et al. Subgroup analysis of baseline susceptibility and early virological response to enfuvirtide in the combined TORO studies. XII International HIV drug resistance workshop : basic principles and clinical implications, 10-14 June 2003, Los Cabos, Mexico, abstract 55.

2/ Mink M et al. Impact of HIV-1 gp41 amino acid substitutions (position 36-45) on susceptibility to T20 (enfuvirtide) in vitro ; analysis of primary virus isolates recovered from patients during chronic enfuvirtide treatment and site-directed mutants in NL4-3. XI International HIV drug resistance workshop : basic principles and clinical implications, 2-5 July 2002, Seville, Spain, abstract 22.

3/ Greenberg ML et al. Enfuvirtide (T-20) and T-1249 resistance : observations from phase II clinical trials of enfuvirtide in combination with oral antiretrovirals and a phase I/II dose-ranging monotherapy trial of T-1249. XI International HIV drug resistance workshop : basic principles and clinical implications, 2-5 July 2002, Seville, Spain, abstract 128.

4/ Greenberg ML et al. Baseline and on-treatment susceptibility to enfuvirtide seen in TORO 1 and TORO 2 to 24 weeks. 10th Conference on Retroviruses and Opportunistic Infections, February 10-14, 2003, Boston, USA, abstract 141.

5/ Chakraborty B et al. Replicative fitness of HIV-1 strains with reduced susceptibility to protease-, reverse transcriptase- and entry (enfuvirtide)-inhibitors. XIII International HIV drug resistance workshop : basic principles and clinical implications, 8-12 June 2004, Tenerife, Spain, abstract 61.

6/ Walmsley SL et al. Development of a new genotypic resistance assay involving the entire gp41 sequence for evaluating resistance to enfuvirtide. XIII International HIV drug resistance workshop : basic principles and clinical implications, 8-12 June 2004, Tenerife, Spain, abstract 134.

7/ Melby T et al. Evolution of enfurvitide resistance in longitudinal samples obtained after continued enfuvirtide dosing post-virological failure. XIV International HIV Drug Resistance Workshop: basic principles and clinical implications, 7-11 June 2005, Québec City, Québec, Canada, abstract 67.