Tables of Rules

PROTEASE INHIBITORS

Nucleoside and Nucleotide reverse transcriptase inhibitors Protease inhibitors

Non-Nucleoside reverse transcriptase inhibitors Fusion inhibitors

HIV - 2 Integrase strand transfer inhibitors

  Mutations associated with resistance Mutations associated with « possible resistance »
IDV
M46I/L
V82A/F/M/S/T [11]
I84A/V [8]
L90M and at least 2 mutations among : K20M/R, L24I, V32I, M36I, I54V/L/M/T, A71V/T, G73S/A, V77I
L90M
SQV/RTV
1000/100 mg BID

G48V
At least 3 mutations among: L10F/I/M/R/V, I15A/V, K20I/M/R/T, L24I, I62V, G73S/T, V82A/F/S/T, I84V, L90M [9]
2 mutations among: L10F/I/M/R/V, I15A/V, K20I/M/R/T, L24I, I62V, G73S/T, V82A/F/S/T, I84V, L90M [9]
NFV
D30N
I84A/V [8]
N88S/D
L90M
V82A/F/S/T and at least 2 mutations among: L10I, M36I, M46I/L, I54V/L/M/T, A71V/T, V77I [1]
LPV/r
At least 4 mutations among: L10F/I/R/V, K20M/R, L24I, L33F, M46I/L, I50V, F53L, I54M/L/T/V, L63P, A71I/L/V/T, V82A/F/S/T, I84V, L90M [3, 4, 5, 21]
I47A [15, 16]
L76V [18, 19]
3 mutations among: L10F/I/R/V, K20M/R, L24I, L33F, M46I/L, I50V, F53L, I54M/L/T/V, L63P, A71I/L/V/T, V82A/F/S/T, I84V, L90M [3, 4, 5, 21]
FPV/RTV
700/100 mg BID
I50V
puce V32I and I47A/V [2, 13, 14]
At least 4 mutations among: L10F/I/V, L33F, M36I, I54A/L/M/S/T/V, I62V, V82A/C/F/G, I84V, L90M [2, 20]
 
ATV/RTV
300/100 mg QD
I50L [6]
N88S [28,29,30]
At least  3 mutations among: L10F/I/V, G16E, L33F/I/V, M46I/L, D60E, A71V/T, I84V, I85V, L90M [7, 12, 22, 31]
2 mutations among: L10F/I/V, G16E, L33F/I/V, M46I/L, D60E, A71V/T, I84V, I85V, L90M [7, 12, 22, 31]
TPV/RTV
500/200 mg BID
At least a score of + 3* :  36I/L/V – 53L/W/Y + 58E + 69I/K/N/Q/R/Y + 89I/M/R/T/V [10, 23]
A score of + 2*: 36I/L/V 53L/W/Y + 58E + 69I/K/N/Q/R/Y + 89I/M/R/T/V [10, 23]

DRV/RTV**
600/100 mg BID



800/100 mg QD

At least 4 mutations among: V11I, V32I, L33F, I47V, I50V, I54L/M, T74P, L76V, I84V, L89V [17, 24, 25, 26, 27]


2 mutations among: V11I, V32I, L33F, I47V, I50V, I54L/M, T74P, L76V, I84V, L89V [17, 24, 25, 26, 27]
3 mutations among: V11I, V32I, L33F, I47V, I50V, I54L/M, T74P, L76V, I84V, L89V [17, 24, 25, 26, 27]

IDV: indinavir, SQV: saquinavir, NFV: nelfinavir, RTV: ritonavir, FPV: fosamprenavir, LPV: lopinavir, ATV:atazanavir, TPV: tipranavir, DRV : darunavir

* Insufficient data for HIV-1 subtype non-B
** Please note that rules are different for DRV/RTV 600/100 mg BID and 800/100 mg QD