Tables of Rules

NUCLEOSIDE AND NUCLEOTIDE REVERSE TRANSCRIPTASE INHIBITORS

Nucleoside and Nucleotide reverse transcriptase inhibitors Protease inhibitors

Non-Nucleoside reverse transcriptase inhibitors Fusion inhibitors

HIV - 2 Integrase strand transfer inhibitors

  Mutations associated with resistance Mutations associated with « possible resistance »
ZDV
T215A/C/D/E/G/H/I/L/N/S/V/Y/F [1, 2, 3, 4]
At least 3 mutations among: M41L, D67N, K70R, L210W, K219Q/E [1, 2, 3, 4]
Q151M
Insertion at codon 69
 
3TC/FTC
K65R [11, 12, 16]
M184V/I
Insertion at codon 69
Q151M
ddI
At least a score of + 2 among: M41L + T69D + 215Y/F + K219Q/E – K70R – M184 V/I [5, 14, 15, 17, 18]
K65R [11, 12]
74V/I [19]
Q151M
Insertion at codon 69
 
d4T
V75A/M/S/T
T215A/C/D/E/G/H/I/L/N/S/V/Y/F [6]
At least 3 mutations among: M41L, D67N, K70R, L210W, K219Q/E [4, 7, 14, 15]
K65R [30, 31, 32]
Q151M
Insertion at codon 69
 
ABC
At least 3 mutations among: M41L, D67N, M184V/I, L210W, T215A/C/D/E/G/H/I/L/N/S/V/Y/F [8, 19, 29]
K65R [9, 11, 12]
L74V/I [24, 25, 26, 27, 28, 29]
Y115F
Q151M
Insertion at codon 69
2 mutations among: M41L, D67N, L210W, T215A/C/D/E/G/H/I/L/N/S/V/Y/F [8, 19, 29]
M184V/I [36]
TDF/TAF
At least 4 mutations among: M41L, E44D, D67N, T69D/N/S, L74V/I, L210W, T215A/C/D/E/G/H/I/L/N/S/V/Y/F [13, 20, 33]
K65R/E/N [9, 10, 11, 12, 34,35,37,38]
Insertion at codon 69
K70E [21, 22, 23]
3 mutations among: M41L, E44D, D67N, T69D/N/S, L74V/I, L210W, T215A/C/D/E/G/H/I/L/N/S/V/Y/F [13, 33, 37, 38]

ZDV: zidovudine, 3TC: lamivudine, FTC: emtricitabine, ddI: didanosine, d4T: stavudine, ABC: abacavir, TDF: tenofovir, TAF : tenofovir alafenamide

References