

INTEGRASE INHIBITOR

Mutations associated with resistance 
Mutations associated with "possible resistance" 
RAL

T66K [10]
E92Q [1, 2]
G118R [10]
F121Y [10]
G140A/S [7]
Y143C/G/H/R/S [1, 3, 4, 5, 8]
Q148E/G/H/K/R [1, 2]
V151L [9]
N155H/S/T [1, 2, 9]
E157Q [2]


EVG 
T66I/A/K [6]
E92Q [6]
F121Y [9]
E138K
G140C/S
P145S [9]
S147G
Q148H/R/K [6]
V151L [9]
N155H/S/T [6, 9]
E157Q [11] 

DTG 
G118R [12,13]
V151L [9]
S153Y
T66K + L74M
E92Q + N155H
E138A/K + Q148H/K/R
G140C/S + Q148H/K/R
Q148R + N155H 
T66K [9]
S153F

RAL: raltegravir, EVG: elvitegravir, DTG: dolutegravir .
References 


