Tables of Rules

NUCLEOSIDE AND NUCLEOTIDE REVERSE TRANSCRIPTASE INHIBITORS

Nucleoside and Nucleotide reverse transcriptase inhibitors Protease inhibitors

Non-Nucleoside reverse transcriptase inhibitors Fusion inhibitors

HIV - 2 Integrase inhibitors

  Mutations associated to resistance Mutations associated to « possible resistance »
ZDV
T215Y/F
At least 3 mutations among : M41L, D67N, K70R, L210W, T215A/C/D/E/G/H/I/L/N/S/V, K219Q/E [1, 2, 3, 4]
Q151M
Insertion at codon 69
  T215A/C/D/E/G/H/I/L/N/S/V [1, 2, 3, 4]
3TC/FTC
M184V/I
Insertion at codon 69
K65R [11, 12, 16]
Q151M
ddI
At least a score of + 2 among: M41L + T69D + L74V/I + T215Y/F + K219Q/E – K70R – M184 V/I [5, 14, 15, 17, 18]
L74V/I without any mutations among M41L, T69D, K70R, M184 V/I, T215Y/F, K219Q/E [19]
Q151M
Insertion at codon 69
K65R [11, 12]
d4T
V75A/M/S/T
T215Y/F [6]
At least 3 mutations among : M41L, D67N, K70R, L210W, T215A/C/D/E/G/H/I/L/N/S/V, K219Q/E [4, 7, 14, 15]
Q151M
Insertion at codon 69
T215A/C/D/E/G/H/I/L/N/S/V [4, 7]
ABC
At least 5 mutations among : M41L, D67N, L74V/I, M184V/I, L210W, T215Y/F [8, 19, 29]
No TAMs and at least 2 mutations among: K65R, L74V/I, Y115F and M184V/I [24, 25, 26, 27, 28, 29]
Q151M
Insertion at codon 69
4 mutations among : M41L, D67N, L74V/I, M184V/I, L210W, T215Y/F [8, 19, 29]
K65R [9, 11, 12]
Y115F
TDF
At least 6 mutations among: M41L, E44D, D67N, T69D/N/S, L74V, L210W, T215Y/F [13, 20]
K65R [9, 10, 11, 12]
Insertion at codon 69
3, 4 or 5 mutations among: : M41L, E44D, D67N, T69D/N/S, L74V, L210W, T215Y/F [13]
K70E [21, 22, 23]

TAMs = M41L, D67N, K70R, L210W, T215Y/F, K219Q/E
ZDV: zidovudine, 3TC: lamivudine, FTC: emtricitabine, ddI: didanosine, d4T: stavudine, ABC: abacavir, TDF: tenofovir
Mutations associated to antiretroviral regimen but with uncertain signification: E44A, D67E/G, T69A, L74I, K219N/R

References