TABLES OF RULES 2004

PROTEASE INHIBITORS

Nucleoside and Nucleotide reverse transcriptase inhibitors Protease inhibitors

Non-Nucleoside reverse transcriptase inhibitors Fusion inhibitors

  Mutations associated to resistance Mutations associated to « possible resistance »
IDV
M46I/L
V82A/F/S/T
I84A/V [8]
L90M and at least 2 mutations among : K20M/R, L24I, V32I, M36I, I54V/L/M/T, A71V/T, G73S/A, V77I
L90M
SQV/RTV
800/100 mg BID

G48V
At least 2 mutations among L24I, I62V, V82A/F/T/S, I84V, L90M [9]
 
NFV
D30N
I84A/V [8]
N88S/D
L90M
V82A/F/S/T and at least 2 mutations among: L10I, M36I, M46I/L, I54V/L/M/T, A71V/T, V77I [1]
fosAPV/RTV
700/100 mg BID
I50V
At least 6 mutations among: L10F/I/V, K20M/R, E35D, R41K, I54V, L63P, V82A/F/S/T, I84V [2, 13]
V32I and I47V [17]
LPV/r
At least 8 mutations among : L10F/I/R/V, K20M/R, L24I, L33F, M46I/L, I50V, F53L, I54M/L/T/V, L63P, A71I/L/V/T, V82A/F/S/T, I84V, L90M [3, 4, 5]
V32I and I47A [14]
6 or 7 mutations among: L10F/I/R/V, K20M/R, L24I, L33F, M46I/L, I50V, F53L, I54M/L/T/V, L63P, A71I/L/V/T, V82A/F/S/T, I84V, L90M [3, 4, 5]
ATV/RTV
300/100 mg QD
I50L [6]
At least 6 mutations among: L10F/I/V, K20I/M/R, L24I, L33F/I/V, M36I/L/V, M46I/L, G48V, I54L/V, L63P, A71I/T/V, G73A/C/S/T, V82A/F/T/S, I84V, L90M [7, 15]
TPV/RTV
500/200 mg BID
At least 8 mutations among: I13L, K20M/R/V, L33F/I, E35D/N, M36I, K45R, M46I/L, I47V, I54A/M/T/V, Q58E, I66F, H69K, A71I/V, T74P, V82F/L/T, I84C/V, T91S [10, 11, 12, 16]
L33F/I and V82F/L/T and I84C/V [16]

IDV: indinavir, SQV: saquinavir, NFV: nelfinavir, RTV: ritonavir, fosAPV: fosamprenavir, LPV: lopinavir, ATV:atazanavir, TPV: tipranavir
Mutations associated to antiretroviral regimen but with uncertain signification: K20T, M46V